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CAS No. 201812-64-8 | DesfluoroMethyl Fluticasone Propionate Disulfide

CAS No. 201812-64-8 | DesfluoroMethyl Fluticasone Propionate Disulfide

Name: DesfluoroMethyl Fluticasone Propionate Disulfide CAS No. 201812-64-8 MF:C48H58F4O10S2 MW:935.09 Purity:97% Package: 10mg,25mg,50mg,100mg,250mg Worldwide Delivery

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Product introduction

Introduction and application of CAS No. 201812-64-8 | DesfluoroMethyl Fluticasone Propionate Disulfide

Synonyms:Androsta-1,4-dien-3-one,17,17'-(dithiodicarbonyl)bis[6,9-difluoro-11-hydroxy-16-Methyl-17-(1-oxopropoxy)-,(6α,11β,16α,17α)-(6'α,11'β,16'α,17'α)-;

FluticasonePropionateDisulfideDimerImpurity;

FluticasoneDisulphaneImpurity;

DesfluoroMethylFluticasonePropionateDisulfide;

FluticasoneImpurity9;

FluticasoneImpurity8(FluticasoneEPImpurityH);

PropionateImpurityH;

FluticasonePropionateEPImpurityH/FluticasoneDisulphaneImpurity/DesfluoromethylFluticasonePropionateDisulfide/17,17′-(Disulphanediyldicarbonyl)bis(6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-dien-17α-yl)dipropanoate

Specification:

ITEMS	SPECIFICATION
CAS	201812-64-8
MF	C48H58F4O10S2
MW	935.09
Melting point	>200°C
Boiling point	905.0±75.0 °C
Density	1.38±0.1 g/cm3
Acidity coefficient	12.20±0.70
Color	off-white to light yellow
Solubility	Soluble in chloroform (a little), DMSO (a little)
Form	Solid
Storage condition	Refrigerator

application:

Fluticasone desfluoromethylpropionate disulfide is a synthetic intermediate for fluticasone propionate. It is mainly used as a pharmaceutical intermediate in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

preparation:

Desfluoromethyl fluticasone propionate disulfide is an impurity generated during the preparation of fluticasone propionate: the first step involves the oxidative cleavage of the hydroxymethyl group at C-17 in flumetasone, chemically known as 6α, 9α-di Fluorine-11β, 17α, 21-trihydroxy-16. α-Methyl-androst-1,4-diene-3,20-dione, via periodic acid to give 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-androsta-1 ,4-diene-3-one-17β-carboxylic acid 2. Activation of the carboxyl group of compound 2 using N,N'-carbonyldiimidazole (CDI) in dimethylformamide (DMF) followed by treatment with H2S gave 6α, 9α-Difluoro-11β,1-7α-dihydroxy-16α-methyl-3-oxo-androste-1,4-diene-17 was prepared using propionyl chloride and triethylamine (TEA). -17 hydroxyl group is esterified to obtain the C-17 hydroxyl group of 6α,9α-difluoro-11β-hydroxy-16[methyl]-[Chemical Formula 3]. α-Methyl-17α-propionyloxy-3-oxo-androst-1,4-diene-17β-thiocarboxylic acid 4. Compound 4 with bromochloromethane using NaHCO3 and dimethylacetamide Cylation of the ide (DMAc) yields S-chloromethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androst-1,4-diene -17β-phosphorothioate.

Package and transportation :

Package: 10mg,25mg,50mg,100mg,250mg